ea0016s20.3 | Translational highlights | ECE2008
Ventura Paula
, Azcona Cristina
, Clemente Maria
, Albisu Marian
, Audi Laura
, Carrascosa Antonio
, Visser Theo
, Moreno Jose C
Generation of H2O2 at the apical membrane of thyroid cells is essential for iodination of thyroglobulin. Dual oxidase 2 (DUOX2) is the catalytic core of the thyroidal H2O2 generator, and its deficiency leads to congenital hypothyroidism (CH) in humans and mice. The Dual oxidase maturation factor 2 (DUOXA2) is a recently identified endoplasmic reticulum (ER)-resident protein required for expression of DUOX2 activity.<p class="abst...